Clostridium difficile classification overestimates hospital-acquired infections

1624Risk Factors for Hospital-Acquired Clostridium difficile

Extraintestinal Clostridium difficile infections.

BACKGROUND  Clostridium difficile causes diarrhea that ranges from a benign, self-limiting antibiotic use-associated disease to a life-threatening pseudomembranous colitis. Clostridium difficile has rarely been isolated in extraintestinal infections. Our objective was to characterize clinical features and risk factors of these infections. METHODS Extraintestinal C. difficile infections (CDIs) w...

Clostridium difficile infections in a tertiary hospital: value of surveillance.

Clostridium difficile is a Gram-positive, spore-forming anaerobic bacillus associated with antibiotic-associated diarrhoea and antibiotic-associated colitis. It is widely distributed in the environment and colonises up to 3e5% of adult humans and 84% of healthy infants without causing symptoms.1 The source of C. difficile may be endogenous or environmental.2 Transmission from patient to patient...

Clostridium difficile infections in China☆

Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in Western countries in the last two decades. However, there is limited information on the status of C. difficile infection in Chinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem of over-prescribing of broad spectrum antibiotics in ...

The effect of hospital-acquired Clostridium difficile infection on in-hospital mortality.

BACKGROUND The effects of hospital-acquired Clostridium difficile infection (CDI) on patient outcomes are incompletely understood. We conducted this study to determine the independent impact of hospital-acquired CDI on in-hospital mortality after adjusting for the time-varying nature of CDI and baseline mortality risk at hospital admission. METHODS This retrospective observational study used ...